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KMID : 0370220050490030244
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Yakhak Hoeji
2005 Volume.49 No. 3 p.244 ~ p.248
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Cytotoxic Constituents of Rhododendron brachycarpum
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강민희/Kang MH
조소연/김현수/김동현/정춘식/Cho SY/Kim HS/Kim DH/Jeong CS
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Abstract
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From the methanol extract of Rhododendron brachycarpum four triterpenes, three phenylpropanes and a diterpene alkaloid were isolated. Their structures were identified as glutinol (1), 3β-hydroxyurs-12-ene (2), β-sitosterol (3), (E)-p-hydroxycinnamic acid hexadecylester (4), (-)-rhododendrol (5), (+)-rhododendrol (6), 3β-hydroxyurs-12-en-28-oic acid (7) and gray-anotoxin I (8) by spectroscopic methods. Compound 8 showed moderate cytotoxicity against five cultured human tumor cell lines with ED50 values of 3.21~4.05 μg/ml. The other compounds were of marginal activity against the tested cell lines.
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